Cilia are microtubule‐based hair‐like structures that project from the surfaces of eukaryotic cells. Cilium formation relies on intraflagellar transport (IFT) to move ciliary proteins such as tubulin from the site of synthesis in the cell body to the site of function in the cilium. A large protein complex (the IFT complex) is believed to mediate interactions between cargoes and the molecular motors that walk along axonemal microtubules between the ciliary base and tip. A recent study using purified IFT complexes has (...) identified a tubulin‐binding module in the two core IFT proteins IFT74 and IFT81 that likely serves to bind and transport tubulin within cilia. Here, we calculate the amount of tubulin required to support the observed cilium assembly kinetics and explore the possibility of multiple tubulin binding sites within the IFT complex. (shrink)

Systematische Annäherung an das Problem einer philosophischen Letztbegründung ethischer Normen -- Konzeption und Funktion der Kommunikationsgemeinschaft in der Normbegründungsstrategie Karl-Otto Apels.

Cognitive science is experiencing a pragmatic turn away from the traditional representation-centered framework toward a view that focuses on understanding cognition as "enactive." This enactive view holds that cognition does not produce models of the world but rather subserves action as it is grounded in sensorimotor skills. In this volume, experts from cognitive science, neuroscience, psychology, robotics, and philosophy of mind assess the foundations and implications of a novel action-oriented view of cognition. Their contributions and supporting experimental evidence show that (...) an enactive approach to cognitive science enables strong conceptual advances, and the chapters explore key concepts for this new model of cognition. The contributors discuss the implications of an enactive approach for cognitive development; action-oriented models of cognitive processing; action-oriented understandings of consciousness and experience; and the accompanying paradigm shifts in the fields of philosophy, brain science, robotics, and psychology. ContributorsMoshe Bar, Lawrence W. Barsalov, Olaf Blanke, Jeannette Bohg, Martin V. Butz, Peter F. Dominey, Andreas K. Engel, Judith M. Ford, Karl J. Friston, Chris D. Frith, Shaun Gallagher, Antonia Hamilton, Tobias Heed, Cecilia Heyes, Elisabeth Hill, Matej Hoffmann, Jakob Hohwy, Bernhard Hommel, Atsushi Iriki, Pierre Jacob, Henrik Jörntell, Jürgen Jost, James Kilner, Günther Knoblich, Peter König, Danica Kragic, Miriam Kyselo, Alexander Maye, Marek McGann, Richard Menary, Thomas Metzinger, Ezequiel Morsella, Saskia Nagel, Kevin J. O'Regan, Pierre-Yves Oudeyer, Giovanni Pezzulo, Tony J. Prescott, Wolfgang Prinz, Friedemann Pulvermüller, Robert Rupert, Marti Sanchez-Fibla, Andrew Schwartz, Anil K. Seth, Vicky Southgate, Antonella Tramacere, John K. Tsotsos, Paul F. M. J. Verschure, Gabriella Vigliocco, Gottfried Vosgerau. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Journal of the History of Philosophy 39.2 (2001) 304-305 [Access article in PDF] Wildfeuer, Armin G. Praktische Vernunft und System. Entwicklungsgeschichtliche Untersuchungen zur ursprünglichen Kant-Rezeption Johann Gottlieb Fichtes. Stuttgart-Bad/Cannstatt : Frommann-Holzboog, 1999. Pp. 596. Cloth, DM 168. The subtitle of this book, a slightly revised dissertation from the University of Bonn (1994), reads: "Investigations into the developmental history of Johann Gottlieb Fichte's original reception of Kant." The work comes (...) to almost 600 pages. The main text is heavily overlaid with detailed footnotes, extensive quotations and supplementary material in smaller print and narrow line spacing. To the reader who is patient enough to face this scholastic mode of presentation, there emerges behind it a valuable contribution to our overall understanding of Fichte's philosophical work in general and its core discipline, the Wissenschaftslehre or first, transcendental philosophy, in particular.In the grand narrative about the development of German idealism Fichte is placed between Kant and Schelling. More precisely, he is typically portrayed as continuing but also revising Kant's work under the double influence of the leading early post-Kantian, Karl Leonhard Reinhold (1758-1823), and the skeptical anti-Kantian and anti-Reinholdian, Gottlob Ernst Schulze (1761-1833), called "Aenesidemus" after the title of his anonymous main work.Wildfeuer's investigations supplement this picture with a detailed consideration of what could be called "Fichte before Fichte": the early development of Fichte's thought, prior to his encounter with Reinhold and prior even to his encounter with Kant (1790). To be sure, Wildfeuer also deals with Fichte's continued philosophical development up through 1794, and he has many interesting things to say about the lasting presence of Fichte's earliest concerns in his more mature work. But the chief merit of the book is the sustained attention it pays to the very beginnings of Fichte's thought.Much of the prehistory of Fichtean philosophy has to be conjectured, given the scarcity of documents about Fichte's years of study (1780-84) and of his work as itinerant tutor (1785-1793). From Fichte's own testimony in his correspondence it is clear that prior to encountering Kant's three Critiques he held a determinist position regarding nature as well as human conduct. Based on some indications in Fichte's later works, Wildfeuer identifies as the chief source of Fichte's determinism the work of Karl Ferdinand Hommel (1722-1781), a professor of law at Leipzig, whom Fichte could have heard as a student and whose pseudonymous treatise Alexander von Joch... On Reward and Punishment According to Turkish Laws (1770) Fichte cites. Hommel (alias von Joch) maintains a deterministic view of human action, while justifying the social practice of punishment and reward. In particular, he maintains the dependence of the will on the intellect and of the latter on sensations or sensory impressions. Wildfeuer refers to this position, as it was temporarily adopted by Fichte, as that of the primacy of the understanding over the will.But Wildfeuer also shows that from early on Fichte's determinist leanings in speculation were counterbalanced by the conviction that feeling, especially feeling in religious matters, is an equally valid source of truth. For Wildfeuer, this early duality of speculation and feeling is the lasting basis of Fichte's life-long concern with reconciling the competing demands of head and heart. In particular this pre-Kantian key concern [End Page 304] in Fichte informs the latter's central systematic occupation with the unity of the mind amidst its differentiation into faculties or kinds of mental activity.Further texts which Wildfeuer examines in pursuit of the pre-Kantian Fichte are his Latin Valedictory Address, given upon graduating from one of Germany's finest secondary schools at the time, the Princely College of Pforta (1780), and the "Aphorisms on Religion and Deism" (1790).On the basis of this material Wildfeuer goes on to reconstruct the distinct reception that each of Kant's three Critiques received by Fichte. According to Wildfeuer, the Critique of Pure Reason originally was read by... (shrink)

The first commented edition of K.W.F. Solger's Vorlesungen über Ästhetik (1819), edited by Giovanna Pinna.

In 1946 Ferdinand Gonseth founded, together with Paul Bernays, Karl Dürr, and Sir Karl Popper, the International Society for Logic and Philosophy of Science. In the next year the first number of Dialectica, a philosophical review devoted mainly to epistemological subjects, was issued. Gonseth's bibliography presents more than 190 items — roughly 25 books, several prefaces, and, for the rest, papers published in numerous reviews. A good deal of his publications concern mathematics — he was appointed professor (...) of mathematics first in Berne and then in Zurich at the well‐known Swiss Federal Institute of Technology — but he has never completely separated his mathematical activities from his philosophical work. (shrink)

Pseudo‐mechanistic explanations in psychology and cognitive neuroscienceThis paper focuses on the level of systems/cognitive neuroscience. It argues that the great majority of explanations in psychology and cognitive neuroscience is “pseudo‐mechanistic.” On the basis of various case studies, Hommel argues that cognitive neuroscience should move beyond what he calls an “Aristotelian phase” to become a mature “Galilean” science seeking to discover actual mechanisms of cognitive phenomena.

This chapter challenges the assumption of attention functioning as a means of preventing consciousness from getting overloaded, and also challenges the assumption of any relationships between management of scarce resources and the original biological function of attention. It emphasizes that attention is directly derived from mechanisms governing the control of basic movements. The author establishes the theoretical stage through discussions on the implications of the brain’s preference to stimulus events and action plans in a feature-based manner and processing information through (...) different mechanisms. The chapter also discusses many empirical findings supporting the conception of action planning and action control having the potential to determine perception and attention. (shrink)

This volume of original essays addresses a range of issues concerning the responsibility individuals have for their actions and for their characters. Among the central questions considered are the following: What scope is there for regarding a person as responsible for his or her character given genetic and environmental factors? Does an account of responsibility provide a legitimate basis for the retributive emotions? Are we ever justified in feeling guilty for occurences over which we have no control? Does responsibility for (...) the consequences of our acts require that they were intended or simply expected? How have a number of influential previous philosophers, including Aristotle, Maimonides, and Spinoza, approached these questions? (shrink)

Religions commonly are taken to provide general orientation in leading one's life. We develop here the idea that religions also may have a much more concrete guidance function in providing systematic decision biases in the face of cognitive-control dilemmas. In particular, we assume that the selective reward that religious belief systems provide for rule-conforming behavior induces systematic biases in cognitive-control parameters that are functional in producing the wanted behavior. These biases serve as default values under uncertainty and affect performance in (...) any task that shares cognitive-control operations with the religiously motivated rule-conforming behavior the biases were originally developed for. Such biases therefore can be unraveled and objectified by means of rather simple tasks that are relatively well understood with regard to the cognitive mechanisms they draw on. (shrink)

This classic remains one of Karl Popper's most wide-ranging and popular works, notable not only for its acute insight into the way scientific knowledge grows, but also for applying those insights to politics and to history.

Traditional approaches to human information processing tend to deal with perception and action planning in isolation, so that an adequate account of the perception-action interface is still missing. On the perceptual side, the dominant cognitive view largely underestimates, and thus fails to account for, the impact of action-related processes on both the processing of perceptual information and on perceptual learning. On the action side, most approaches conceive of action planning as a mere continuation of stimulus processing, thus failing to account (...) for the goal-directedness of even the simplest reaction in an experimental task. We propose a new framework for a more adequate theoretical treatment of perception and action planning, in which perceptual contents and action plans are coded in a common representational medium by feature codes with distal reference. Perceived events (perceptions) and to-be-produced events (actions) are equally represented by integrated, task-tuned networks of feature codes – cognitive structures we call event codes. We give an overview of evidence from a wide variety of empirical domains, such as spatial stimulus-response compatibility, sensorimotor synchronization, and ideomotor action, showing that our main assumptions are well supported by the data. Key Words: action planning; binding; common coding; event coding; feature integration; perception; perception-action interface. (shrink)

Kant's Reason develops a novel interpretation of Kant’s conception of reason and its philosophical significance, focusing on two claims. First, it argues that Kant presents a powerful model for understanding the unity of theoretical and practical reason as two manifestations of a unified capacity for theoretical and practical understanding (or “comprehension”). This model allows us to do justice to the deep commonalities between theoretical and practical rationality, without reducing either to the other. In particular, through it, we see why the (...) activities of both theoretical and practical reason are governed by a version of the Principle of Sufficient Reason, while also seeing why reason is essentially autonomous. At the same time, Kant's Reason also reads Kant as presenting us with a compelling picture of the role that reason (as a capacity or power) should play in a systematic approach to foundational philosophical questions. In doing so, it argues for an account of the fundamental norms that apply to rational beings that treats as fundamental neither substantive reasons or values nor merely structural rationality, but instead a robust conception of reason as a power or capacity — namely, the capacity for theoretical and practical understanding. The result is a form of “rational constitutivism” – one which contrasts both with the forms of “reasons fundamentalism” that are currently fashionable and the forms of “agency-first constitutivism” that have dominated much of Kantian metaethics. In this sense, the aim of the book is to vindicate Kant’s insistence that his philosophy represents nothing more or less than reason’s implicit self-understanding coming to explicit and systematic self-consciousness. (shrink)

Realist evaluation has gained prominence in the field of evaluation in recent years. Its theory-driven approach to explaining how and why programmes work or not makes it attractive to many novices, early career researchers, and organizations implementing various programmes globally and relevant to policymakers and programme implementers. While realist evaluation seeks to be pragmatic, adopting principles and methods that can be used to help focus an evaluation, its deep ontological and epistemological foundations make its application in real-life situations challenging. In (...) this paper, we seek to unpack the key tenets scaffolding the practical application of realist evaluation. Although Pawson and Tilley foreground realist evaluation in applied scientific realism, we argue that an amalgam of scientific and critical realist principles underpins realist evaluation. We unpack these principles and illustrate how they fit into each other to provide a cogent theoretical foundation for realist evaluation. (shrink)

Brings together the key writings of Ferdinand Christian Baur across theology, biblical studies, early Christian history, and philosophy, showing his crucial role in the development of 19th-century thought.